Neuroplasticity (NP) is the main basis on which neurorehabilitation (NR) is based. At the same time, neurovirtuality (NV) is based on the influence of virtual reality (VR) on NP. Therapy with VR promotes the creation of sensory scenarios parallel to the real environment, resulting in an enhancement of NP, and conducting to brain decoding and interpretation of these scenarios through a two-way process. More and more current lines of research in the field of NR include VR in the methodology used, with the aim of enhancing through NV the neuroplastic mechanisms of recovery, obtaining positive results in various neurological and psychiatric disorders. However, the exact mechanisms that can lead to significant individualized improvement are not yet fully known. Therefore, more studies are needed to elucidate respondent’s patient profile, as well as the creation of different RV subtypes to maximize the results obtained according to patient’s characteristics.