Introduction: Adherence is a key concept in chronic diseases that can be influenced by multiple variables. In the case of epilepsy, therapeutic adherence has particular considerations in virtue of the characteristics of this disease. Material and methods: We conducted a review of the literature on therapeutic adherence in epilepsy. Results: There are some classical predictors of adherence in epilepsy that can be classified according to whether they are dependent on the patient, the disease, or the drug. In recent years, specific variables have been investigated such as the type of crisis, intellectual disability, economic or educational level, and coexistence with comorbid psychiatric pathologies. Conclusions: Low adherence in epilepsy is a constant in neurological clinical practice: so, it is necessary to investigate its existence in the clinical interview. Several variables determinates lack of adherence in epileptic patients. Some may seem obvious, but others are not. It is necessary that we know how to identify these predictors of lack of adherence
to try to compensate them as much as possible.